Bayesian Effect Estimation Accounting for Adjustment Uncertainty

Bayesian effect estimation accounting for adjustment uncertainty.

Model-based estimation of the effect of an exposure on an outcome is generally sensitive to the choice of which confounding factors are included in the model. We propose a new approach, which we call Bayesian adjustment for confounding (BAC), to estimate the effect of an exposure of interest on the outcome, while accounting for the uncertainty in the choice of confounders. Our approach is based...

Causal effect estimation in sequencing studies: a Bayesian method to account for confounder adjustment uncertainty

Estimating the causal effect of a single nucleotide variant (SNV) on clinical phenotypes is of interest in many genetic studies. The effect estimation may be confounded by other SNVs as a result of linkage disequilibrium as well as demographic and clinical characteristics. Because a large number of these other variables, which we call potential confounders, are collected, it is challenging to s...

Accounting for haplotype phase uncertainty in linkage disequilibrium estimation.

The characterization of linkage disequilibrium (LD) is applied in a variety of studies including the identification of molecular determinants of the local recombination rate, the migration and population history of populations, and the role of positive selection in adaptation. LD suffers from the phase uncertainty of the haplotypes used in its calculation, which reflects limitations of the algo...

Bayesian Ambient Noise Inversion for Geoacoustic Uncertainty Estimation: Final report

Bayesian Ambient Noise Inversion for Geoacoustic Uncertainty Estimation

Estimation of seabed geoacoustic parameters in shallow water by remote sensing remains a challenging task due to constraints on hardware, data collection and analysis, and cost of maritime surveys. This work focuses on the application of two techniques that might offer a solution to those constraints: the use of ambient noise to probe the seabed, and Bayesian inversion of these data to estimate...